![]() ![]() ![]() The objective of this study was to synthesize and evaluate in vitro CUR monoketone analog dibenzalacetone (DBA 1) and its non-phenolic, methoxy ( 2–4) and chloro ( 5) derivatives for better stability and bioavailability against T. cruzi. However, because of its chemical instability, poor cellular uptake and limited bioavailability it is not suitable for clinical use. plant rhizomes and roots), exhibits antiparasitic activity against protozoan parasites in vitro. Curcumin (CUR), the major constituent of turmeric spice (dry powder of Curcuma longa L. Chagas disease is a tropical disease caused by the protozoan parasite Trypanosoma cruzi and currently affects millions of people worldwide. ![]()
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